02642cam a22003615a 4500001001000000003000400010005001700014008004100031020001800072040003600090082002000126245008800146250001200234260005600246300002700302490002300329504005100352505002800403520106800431650003901499650003301538650002701571651001001598653003701608700002901645776003501674942000801709999001701717952013401734952014401868952013402012952013402146017626671OSt20171226105758.0151116t2016    sz     frbf   001 0 eng d  a9783319053912  aStDuBDSbengcStDuBDSdEG-ScBUE04a615.19bDRU22200aDrug discovery and evaluation :bpharmacological assays /cedited by Franz J. Hock.  a4th ed.  aCham :bSpringer International Publishing,cc.2016.  a4 v. :bill. ;c24 cm.0 aSpringer reference  aIncludes bibliographical references and index.  av. 1. -- v. 2. -- v. 3.  aThe 4th edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the more than 1,000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this 4th edition, all existing chapters have been revised and completely updated. A large number of assays were added. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis, - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. New chapters are added such as Auditory Pharmacology, Oncology Activity, Stem Cells, Omics, Personalized Medicine, etc 7aPharmacology, Experimental.2BUEsh 7aDrugsxDesign.2BUEsh930136 7aDrugsxTesting.2BUEsh  2BUEsh  bPPhrmcOctober2017cDecember20171 aHock, Franz J.,eeditor.08iPrint version :z9783319053912  2ddc  c25528d25500  00102ddc40708BaccahaMAINbMAINc1STd2017-10-31ePurchasel0o615.1903 DRUp000042353r2025-07-15 00:00:00yREFERENCEzv. 4.  00102ddc40708BaccahaMAINbMAINc1STd2017-12-26ePurchaseg32500.00l0o615.1903 DRUp000047016r2025-07-15 00:00:00yREFERENCEzv. 1.  00102ddc40708BaccahaMAINbMAINc1STd2017-12-26ePurchasel0o615.1903 DRUp000047017r2025-07-15 00:00:00yREFERENCEzv. 2.  00102ddc40708BaccahaMAINbMAINc1STd2017-12-26ePurchasel0o615.1903 DRUp000047018r2025-07-15 00:00:00yREFERENCEzv. 3.