02858cam a22003255a 45000010009000000050017000090080041000260200026000670200023000930400079001160820020001952450128002152600043003433000046003864900065004325000024004975040041005215050845005625050786014076500037021936500031022306510010022616530023022716550024022947000026023187000029023449420008023739990017023819520134023981541736020151026135042.0080814t2009    njua   frb    001 0 eng d  a9780470225554 (cloth)  a0470225556 (cloth)  aDNLM/DLCcDLCdNLMdBAKERdBTCTAdYDXCPdC#PdBWXdIXAdDLCdEG-ScBUEbeng04a615.19222bDRU00aDrug efficacy, safety, and biologics discovery :bemerging technologies and tools /c[edited by] Sean Ekins, Jinghai J. Xu.  aHoboken :bJohn Wiley & Sons,cc.2009.  axvi, 408 p. :bill. (some col.) ;c25 cm.0 aWiley series on technologies for the pharmaceutical industry  aIndex : p. 381-408.  aIncludes bibliographical references.0 aFocus on the fundamentals : toward better therapeutic index prediction / Jinghai J. Xu and Li J. Yu -- High-throughput protein-based technologies and computational models for drug development, efficacy, and toxicity / Leonidas G. Alexopoulos, Julio Saez Rodriguez, and Christopher W. Espelin -- Cellular systems biology applied to preclinical safety testing : a case study of CellCiphr profiling / Lawrence Vernetti ... [et al.] -- Systems pharmacology, biomarkers, and biomolecular networks / Aram S. Adourian ... [et al.] -- Zebrafish models for human diseases and drug discovery / Hanbing Zhong, Ning-Ai Liu, and Shuo Lin -- Toxicity pathways and models : mining for potential side effects / Sean Ekins and Josef Scheiber -- Computational systems biology modeling of dosimetry and cellular response pathways / Qiang Zhang ... [et al.] --0 aStem cell technology for embryotoxicity, cardiotoxicity, and hepatotoxicity evaluation / Julio C. Davila ... [et al.] -- Telemetry technology for preclinical drug discovery and development / Yi Yang --Nanotechnology to improve oral drug delivery / Mayank D. Bhavsar, Shardool Jain, and Mansoor M. Amiji -- Functional glycomics and the future of glycomic drugs / Ram Sasisekharan and Karthik Viswanathan -- Modeling efficacy and safety of engineered biologics / Jeffrey R. Chabot and Bruce Gomes -- Regulation of gene expression by small, non-coding RNAS : practical applications / Roman Herrara and Eric Tien -- Future perspectives of biological engineering in pharmaceutical research : the paradigm of modeling, mining, manipulation, and measurements / Jinghai J. Xu ... [et al.]. 0aPharmaceutical technology2BUEsh 0aBiological products2BUEsh  2BUEsh  bPPhrmcOctober2015  vReading book9342321 aEkins, Sean,eeditor.1 aXu, Jinghai J.,eeditor.  2ddc  c20990d20962  00102ddc40708BaccahaMAINbMAINc1STd2015-10-26ePurchasel2m10o615.19 DRUp000031188r2025-07-15 00:00:00s2021-07-07yBB